elysiumhealthMay 24, 2024, 12:03 PM

Special edition: New longevity insights from Index

Basis and biological age and more ELYSIUM New longevity insights from Index In this special edition of our newsletter, we're updating you on two important developments coming out of our Aging

Elysium

New longevity insights from Index

In this special edition of our newsletter, we’re updating you on two important developments coming out of our Aging Research Center—and we hope they’ll get you excited about participating in longevity research. The first is that long-term use of Basis or Signal is associated with slower biological aging, as well as slower rates of aging of the liver, kidneys, and the inflammation and metabolic systems. The second update is that we’re preparing to enroll participants in our new sleep and longevity study, TIME-ZZZ, developed in partnership with sleep expert and Professor of Circadian Neuroscience at the University of Oxford Russell Foster, Ph.D. Read on for details and to learn how you can participate.

Long-term use of Basis or Signal is associated with slower biological aging

Index users who enroll in TIME-A are helping to elucidate what an ideal longevity routine might look like—both in their own lives and for the Elysium community more broadly. New data on the relationship between Basis and Signal and slower biological aging illustrates this point. We encourage all Index users to enroll to help us better understand these promising results, and to track their own biological age over time as they use Elysium products. Here’s what we learned so far.

Taking Basis consistently for two or more years was associated with a ~5% slower rate of aging, according to epigenetic data, including from our TIME-A longevity study.* These individuals with a slower overall rate of aging also had slower rates of aging of the liver, kidneys, inflammation, and metabolic systems. We saw a similar ~5% reduction in the rate of aging associated with the use of Signal for one or more years.

We view these findings as an important step forward in NAD+ and longevity research. For the last century, calorie restriction (CR) has been the gold standard for aging interventions. A recent human study published in Nature Aging demonstrated a 2-3% reduction in the rate of aging in individuals who ate 12% fewer calories over two years. The longevity benefits of CR are mediated, in part, by sirtuins—also known as “longevity genes.” Sirtuin activators, like NAD+ boosters, are considered calorie restriction mimetics because they upregulate pathways activated by CR.

We look forward to sharing the full results when we publish our findings—and to continuing to offer direct access to breakthroughs in longevity science.

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*The epigenetic data came from 473 study participants who self-reported their supplement use. Biological age can also be influenced by various environmental and lifestyle factors and changes.

Understand your aging—in the highest resolution

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Track 10 different aspects of aging, including the biological age of nine systems, using epigenetics technology that outperforms the competition. And become eligible for participation in our Aging Research Center studies like TIME-A and TIME-ZZZ.

For a limited time, take an additional $50 off the already-reduced price of Index with code MDW50.*

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COMING SOON

Translational Initiative to Map Epigenetics in Sleep (TIME-ZZZ)

TIME-ZZZ is our new longevity study focused on sleep. Designed with renowned sleep expert Russell Foster, Ph.D., TIME-ZZZ seeks to advance our understanding of the association between sleep quality, chronotype, mental health, and biological aging. Foster serves as Professor of Circadian Neuroscience and the Head of Department of Ophthalmology at the University of Oxford and is a member of the Elysium Health Scientific Advisory Board.

Who are the principal investigators?

Russell Foster, Ph.D., University of Oxford

Dayle Sampson, Ph.D., Elysium Health

Who is eligible?

Anyone who has ever taken an Index test registered through Elysium Health.

How do I participate?

Answer a series of short questionnaires (“activities”) covering topics related to sleep quality and mental health.

What are the benefits?

•	Enjoy a special webinar with Dr. Foster on the science of sleep

•	First 100 to enroll and complete the questionnaires will receive a signed copy of Foster’s book Life Time

•	Receive study insights and contribute to advancing clinically validated interventions and health monitoring tools for longevity

Where can I learn more?

•	Additional study details can be found on clinicaltrials.gov under the identifier NCT06333301. Look out for an email from us when enrollment opens in June.

© 2024 Elysium Health Inc., 434 Broadway, Floor 2, New York, NY 10013

Call or text: (888) 220-6436 care@elysiumhealth.com Unsubscribe View in Your Browser

*MDW50 valid on Index only. Promotion ends May 31, 2024 at 11:59PM PT. Code must be applied at checkout.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition. Unless advised by your healthcare professional, biological age should not be used to determine or alter any age-related health or medical treatments based on your chronological age.

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